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| Survival activating factor enhancement ： ウィキペディア英語版 |
Survival activating factor enhancement
Survivor Activating Factor Enhancement (SAFE) is a metabolic pathway. It is an intrinsic protective signaling programme to limit cell death activated by the heart. This pathway allows ischaemic postconditioning that helps protect against reperfusion injury.〔Ischaemic postconditioning protects against reperfusion injury via the SAFE pathway. Lydia Lacerda, Sarin Somers, Lionel H. Opie and Sandrine Lecour, Cardiovasc. Res., 2009, 84 (2), pages 201-208, 〕 This path involves the activation of a transcription factor called ''signal transducer and activator of transcription 3'' (STAT3).〔When are pro-inflammatory cytokines SAFE in heart failure? Lecour Sandrine and James Richard, European heart journal, 2011, vol. 32, no6, pages 680-685, 〕
== Activation ==
A 2011 study concludes, “Our data demonstrate that both melatonin and resveratrol, as found in red wine, protect the heart in an experimental model of myocardial infarction via the SAFE pathway.”
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